ea0029p761 | Endocrine Disruptors | ICEECE2012
Tarnow P.
, Hunecke D.
, Luch A.
Introduction: After binding its ligand, a conformational change in estrogen receptor alpha (ERĪ±) occurs, leading to subsequent homodimerization of two monomeric ERs. The dimer then binds to specific DNA-elements or to other transcription factors already bound on gene promoters to regulate target gene expression. Protein-fragment complementation assays in general are simple tools to monitor proteinĀprotein interactions and are useful to visualize the subcellular sites...